Chromenes of polyketide origin from Peperomia villipetiola

Karina J. Malquichagua Salazar, Guillermo E. Delgado Paredes, Luis Ripalda Lluncor, Maria Claudia Max Young, Massuo Jorge Kato

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32 Scopus citations


An extract of leaves and stems of Peperomia villipetiola has been found to contain myristicin (3-methoxy-4,5-methylenedioxy-allylbenzene) and seven chromenes, whose structures are methyl 5-hydroxy-7-methyl-2,2-dimethyl-2H-1- chromene-6-carboxylate (1), methyl 5-methoxy-7-methyl-2,2-dimethyl-2H-1- chromene-8-carboxylate (2), methyl 7-hydroxy-5-methyl-2,2-dimethyl-2H-1- chromene-6-carboxylate (3), methyl 7-methoxy-5-methyl-2,2-dimethyl-2H-1- chromene-6-carboxylate (4), 5-methanol-7-hydroxy-2,2-dimethyl-2H-1-chromene-6- carboxylic acid (5), 5-methanol-7-methoxy-2,2-dimethyl-2H-1-chromene-6- carboxylic acid (6), and methyl 5-acetoxymethanol-7-hydroxy-2,2-dimethyl-2H-1- chromene-6-carboxylate (7). A biosynthetic rationale for 1-7 suggests that orsellinic acid may be a common intermediate. The anti-fungal activities of the chromenes were measured bioautographically against Cladosporium cladosporioides and Cladosporium sphaerospermum: compounds 6 and 7 were found to be the most active.

Original languageEnglish
Pages (from-to)573-579
Number of pages7
Issue number5
StatePublished - Mar 2005

Bibliographical note

Funding Information:
The work was funded by grants from CNPq. The authors thank Ms. Consuelo Rojas Idrogo (Universidad Pedro Ruiz Gallo, Lambayeque, Peru) for collecting the plant material and Santos Llatas Quiroz for the botanical identification.


  • Anti-fungal activity
  • Chromenes
  • Orsellinic acid
  • Peperomia villipetiola
  • Piperaceae
  • Structural elucidation


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