In vitro antifungal activity of crude extracts of Piper tuberculatum

Translated title of the contribution: Actividad antifúngica in vitro de extractos crudos de Piper tuberculatum

Zahyda G.F. Palacios, Guillermo E. Delgado, Mario C. Moreno, Massuo J. Kato, Consuelo Rojas

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Piper tuberculatum Jacq. (Piperaceae) is used in traditional Peruvian medicine as anti-inflammatory and disinfectant of wounds in humans and domestic animals. This species contains amides bearing isobutyl, pyrrolidine, dihydropyridone and piperidine moieties. The aim of this work was to investigate antifungal activity of crude extracts from the spikes, leaves and stems of wild plants extracted with CH2Cl2:MeOH (2:1), EtOH, decoction, and in vitro plants extracted with CH2Cl2:MeOH (2:1). The crude extracts showed antifungal activity on Trichophyton rubrum, Mycosporum canis y M. gypseum. The minimum inhibitory concentration (MIC) observed with CH2Cl2:MeOH (2:1), EtOH and decoctions extracts against T. rubrum, M. canis and M. gypseum was 0,1 mg/mL for spikes and leaves, and 0,1 to 0,5 mg/mL for stems. The inhibition of growth using in vitro plants on T. rubrum and M. canis was 100% in 0,5 mg/mL, and 95% on M. gypseum 95% using 1,5 mg/mL of concentration.

Translated title of the contributionActividad antifúngica in vitro de extractos crudos de Piper tuberculatum
Original languageSpanish
Pages (from-to)209-214
Number of pages6
JournalRevista Peruana de Biologia
Issue number2
StatePublished - Dec 2009

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© Facultad de Ciencias Biológicas UNMSM


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